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He was correct. In 2006, as the world watched in awe as the most populous country in world began to use clomiphene citrate treatment treat its growing population of elderly patients, the drug had not gotten critical mass of approvals required to break even. The Danish drugmaker Novartis, that had bought the rights to drug in 1997, had seen its share price plummet and saw potential loss of billions upon dollars. It needed to produce a success justify the cost and risks. company announced in April 2006 that it had found the answer.
Clomiphene could be a blockbuster drug.
Clomiphene citrate treatment became a blockbuster therapy for depression. It's a type of drug known as an atomoxetine (marketed Cipramil) which the FDA has approved to treat depression in women and men.
While clomiphene treatment is known for the rapid effects it has on people suffering from major depression, it's been proven to have benefits Clomid 25mg $150.7 - $0.56 Per pill
for a wider variety of disorders.
According to a study published in the January 2012 issue of American Journal Psychiatry, clomiphene treatment has shown positive results in treating bipolar disorder, anxiety attention deficit hyperactivity and chronic pain.
Cipramil works by altering the normal balance in brain's chemical messengers that transmit nerve impulses from one cell Excelmed generic drugstore
to the next. This may explain why clomiphene appears to work so well in treating depression.
But clomiphene has a major limitation.
Because it is a powerful antidepressant, has to be combined with another drug that acts on the nervous system to produce an antidepressant effect.
The downside to this combination is that, unlike antidepressants, clomiphene has a risk of inducing suicidal thoughts in patients. And because it has a risk of inducing suicidal thoughts, clomiphene treatment also carries another danger to patient safety.
One of the potential side effects with clomiphene is the possibility of depression itself causing suicide.
The side effects were not considered an issue for Cipramil as it's a highly selective drug that targets the most severe symptoms of depression, making it ideal for certain patients. But clomiphene is often used in combination with other medications, particularly antidepressants.
To overcome this, Novartis set out to develop a drug specifically designed for the treatment of depression.
The company tested safety and efficacy of a new drug that they developed targets the same brain area clomiphene was targeting. They called it Cipramil in the USA, Ciproxin Fluconazol tabletten bestellen
Europe, and Clomiphene in the rest of world. It showed similar effects to a placebo controlled study of clomiphene and is FDA approved for depression.
So why did Novartis fail to win approval for the drug? One reason is that clomiphene was just too expensive. The other reason is that clomiphene an atomazine, similar to the molecule that makes up Cipramil. These atomazine compounds have the ability to cross blood-brain barrier. While clomiphene is an atomazine, it will not cross the blood-brain barrier because is a disulphide.
In the United Kingdom, atomazines such as sodium cyclamate are not permitted as the sole treatment for depression. This means that clomiphene treatment is still not available in the US.
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